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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Periplocin, TNF-related apoptosis inducing ligand
Phytochemical Name Periplocin (PubChem CID: 14463159 )
Anticancer drug Name TNF-related apoptosis inducing ligand (PubChem CID: / )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 960
Ref_1
Pair Name Periplocin, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2B70.1] Esophageal squamous cell carcinoma Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BIRC5 hsa332
Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP8 hsa841
Down-regulation Activity CTNNB1 hsa1499
Down-regulation Phosphorylation CTNNB1 hsa1499
Down-regulation Activity FOXP3 hsa50943
Up-regulation Expression TNFRSF10A hsa8797
Up-regulation Expression TNFRSF10B hsa8795
In Vitro Model Eca-109 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_6898
TE-1 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1759
YES-2 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_E322
KYSE-30 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1351
KYSE-410 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1352
KYSE-510 Esophageal squamous cell carcinoma Homo sapiens (Human) CVCL_1354
Result Our data suggest that CPP and TRAIL could be further explored as potential therapeutic approach for esophageal cancer.
Combination Pair ID: 611
Ref_2
Pair Name Periplocin, TNF-related apoptosis inducing ligand
Disease Info [ICD-11: 2B72] Gastric cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression BID hsa637
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression CASP8 hsa841
Up-regulation Expression EGR1 hsa1958
Up-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Expression MCL1 hsa4170
Up-regulation Expression TNFRSF10A hsa8797
Up-regulation Expression TNFRSF10B hsa8795
In Vivo Model The proceduresusing animals were approved by the Animal Care and Use Committee.SGC-7901 cells (1×10⁵/100μL/mouse) were suspended in 0.9%physiological saline and subcutaneously injected into the right flank ofeach mouse.
Result Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway
03. Reference
No. Title Href
1 Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy. J Exp Clin Cancer Res. 2019 Dec 21;38(1):501. doi: 10.1186/s13046-019-1498-z. Click
2 Antitumor Effect of Periplocin in TRAIL-Resistant gastric cancer cells via upregulation of death receptor through activating ERK1/2-EGR1 pathway. Mol Carcinog. 2019 Jun;58(6):1033-1045. doi: 10.1002/mc.22991. Click
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